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Pauci-immune crescentic glomerulonephritis in limited cutaneous systemic sclerosis

Identifieur interne : 001365 ( Main/Exploration ); précédent : 001364; suivant : 001366

Pauci-immune crescentic glomerulonephritis in limited cutaneous systemic sclerosis

Auteurs : P. T. Chan [République populaire de Chine] ; C. C. Mok [République populaire de Chine]

Source :

RBID : ISTEX:B307FE4C69CBB600642596BF10C63007ED15C1D4

English descriptors

Abstract

Abstract: Pauci-immune necrotizing glomerulonephritis is a form of a rapidly progressive glomerulonephritis that is associated with the anti-neutrophil cytoplasmic antibodies (ANCA). ANCA-associated pauci-immune glomerulonephritis may be secondary to rheumatic diseases. We report on a patient with limited cutaneous systemic sclerosis who presented with subacute onset of nephritic syndrome and renal insufficiency. Her myeloperioxidase ANCA titer was elevated and renal biopsy confirmed pauci-immune crescentic glomerulonephritis, which was stabilized with high-dose glucocorticoid and cyclophosphamide. ANCA-associated necrotizing glomerulonephritis is rarely reported in systemic sclerosis and a systematic review is presented.

Url:
DOI: 10.1007/s10067-012-2010-8


Affiliations:


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Le document en format XML

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